MDR and Nematode Parasites

Chemotherapy remains the foremost available tool for the control of nematode parasites. However, the substantial use of anthelmintics, combined with a scarcity of new anthelmintic classes, has led to a gradual increase in the resistance of nematode parasites to these compounds. Multi-Drug Resistance (MDR) in economically important livestock nematodes, such as Haemonchus contortus enables the parasite to effectively ‘escape’ the effects of existing anthelmintics and represents a major obstacle to sustainable livestock farming and food production [1]. The growth in anthelmintic resistance has led to an increasing need for novel chemotherapeutic compounds.